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两种新发现的肝炎病毒及其流行病学研究近况

作者:大江 | 时间:2014-10-6 10:25:53 | 阅读:513| 显示全部楼层

      
Two kinds of newly discovered hepatitis virus and present status of their epidemiological research

杜兰英  何军  王海涛  庄辉 

关键词:肝炎病毒HGVTTV
分类号:R472 文献标识码:B



  1989年以前,人们以“非甲非乙型肝炎”表示那些未知病原所致的肝炎。丙型肝炎病毒(HCV)的发现打破了这种僵局,但发现它是肠道外非甲非乙型肝炎的主要病原〔1〕。后来,Reyes等成功地分离出戊型肝炎病毒(HEV),而它则是经肠道传播非甲非乙型肝炎的主要病原〔2〕。1994年,Deka等〔3〕用一名患有散发性非甲非乙型肝炎的法国病人粪便接种猕猴,在猕猴体内找到一种直径为27~32 nm的病毒颗粒,其基因组长约20kb,过早乐观地将其命名为HFV,后因该项研究未能重复进行而难以为人们接受。另外一些病毒,如EBV、CMV、HSV等,在某些特定条件下亦能导致肝炎发生,但此种情况极少见。尽管如此,仍有20%的急性肝炎,3%~9%的肝硬化,30%~50%的暴发性肝炎找不到可解释的原因。……

作者单位:杜兰英(北京大学基础医学院微生物学系,北京 100083) 
     何军(北京大学基础医学院微生物学系,北京 100083) 
     王海涛(北京大学基础医学院微生物学系,北京 100083) 
     庄辉(北京大学基础医学院微生物学系,北京 100083) 

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