Two kinds of newly discovered hepatitis virus and present status of their epidemiological research
杜兰英 何军 王海涛 庄辉
关键词：肝炎病毒HGVTTV
分类号：R472 文献标识码：B
1989年以前，人们以“非甲非乙型肝炎”表示那些未知病原所致的肝炎。丙型肝炎病毒(HCV)的发现打破了这种僵局，但发现它是肠道外非甲非乙型肝炎的主要病原〔1〕。后来，Reyes等成功地分离出戊型肝炎病毒(HEV)，而它则是经肠道传播非甲非乙型肝炎的主要病原〔2〕。1994年，Deka等〔3〕用一名患有散发性非甲非乙型肝炎的法国病人粪便接种猕猴，在猕猴体内找到一种直径为27～32 nm的病毒颗粒，其基因组长约20kb，过早乐观地将其命名为HFV，后因该项研究未能重复进行而难以为人们接受。另外一些病毒，如EBV、CMV、HSV等，在某些特定条件下亦能导致肝炎发生，但此种情况极少见。尽管如此，仍有20％的急性肝炎，3％～9％的肝硬化，30％～50％的暴发性肝炎找不到可解释的原因。……
作者单位：杜兰英（北京大学基础医学院微生物学系，北京 100083）
何军（北京大学基础医学院微生物学系，北京 100083）
王海涛（北京大学基础医学院微生物学系，北京 100083）
庄辉（北京大学基础医学院微生物学系，北京 100083）
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